Calculate Apoquel Dosage
Available Apoquel Tablet Sizes
Initial Therapy
0.4-0.6 mg/kg twice daily for up to 14 days. Rapidly controls itching and inflammation.
Maintenance
0.4-0.6 mg/kg once daily for long-term control. Same dose, reduced frequency.
Fast Acting
Starts working within 4 hours. Maximum effect typically seen within 24 hours.
Apoquel Dosage Chart by Weight
| Weight | Dose Range | Tablet | Tablets/Dose |
|---|---|---|---|
| 6.6-9.9 lbs (3.0-4.4 kg) | 1.2-2.6 mg | 3.6 mg | ½-1 |
| 10-14.9 lbs (4.5-5.9 kg) | 1.8-3.5 mg | 5.4 mg | ½-1 |
| 15-19.9 lbs (6.0-8.9 kg) | 2.4-5.3 mg | 5.4 mg | 1 |
| 20-29.9 lbs (9.0-13.4 kg) | 3.6-8.0 mg | 5.4 mg | 1-2 |
| 30-44.9 lbs (13.5-19.9 kg) | 5.4-12 mg | 16 mg | ½-1 |
| 45-59.9 lbs (20-26.9 kg) | 8-16 mg | 16 mg | 1 |
| 60-89.9 lbs (27-39.9 kg) | 10.8-24 mg | 16 mg | 1-2 |
| 90-129.9 lbs (40-59.9 kg) | 16-36 mg | 16 mg | 2 |
| 130+ lbs (60+ kg) | 24+ mg | 16 mg | 2-3 |
* Based on 0.4-0.6 mg/kg dosing. Always verify with your veterinarian. Tablets should not be split.
What is Apoquel?
Apoquel (oclacitinib maleate) is a prescription medication manufactured by Zoetis for dogs. It is FDA-approved to control itching associated with allergic dermatitis and to control atopic dermatitis in dogs 12 months of age and older.
Unlike steroids, Apoquel is a targeted therapy that works by inhibiting Janus kinase (JAK) enzymes, specifically JAK1 and JAK3. These enzymes are involved in the itch and inflammation cycle. By blocking these enzymes, Apoquel quickly reduces itching without many of the side effects associated with steroids.
Key Benefits:
- Fast-acting relief (within 4 hours)
- Targeted mechanism of action
- Safe for long-term use in most dogs
- Can be used alongside other medications
- Available in convenient tablet form
Who Should Not Take Apoquel
Per the FDA-approved Apoquel label, oclacitinib is not for use in dogs under 12 months of age, dogs with serious infections, or breeding, pregnant, or lactating dogs. Because Apoquel modulates the immune system, it may increase susceptibility to infection (including demodicosis) and has been associated with the development or exacerbation of neoplastic (tumor) conditions in some dogs. [1]
This is prescription-only, safety-relevant information — it does not replace an exam by a licensed veterinarian, who can weigh your dog's individual health history before starting or continuing Apoquel.
Learn more about Apoquel:
Frequently Asked Questions
What is the correct Apoquel dosage for dogs?
The standard Apoquel (oclacitinib) dosage for dogs is 0.4-0.6 mg per kg (0.18-0.27 mg per lb) of body weight. For initial therapy, this dose is given twice daily for up to 14 days. For maintenance therapy, the same dose is given once daily. Always follow your veterinarian's specific instructions.
How do I calculate Apoquel dosage by weight?
To calculate Apoquel dosage: multiply your dog's weight in kilograms by 0.4-0.6 mg. For example, a 10 kg (22 lb) dog needs 4-6 mg per dose. Apoquel comes in 3.6 mg, 5.4 mg, and 16 mg tablets. Our calculator above automatically determines the best tablet size for your dog.
What tablet sizes does Apoquel come in?
Apoquel (oclacitinib) is available in three tablet strengths: 3.6 mg (for dogs 3-4.4 kg), 5.4 mg (for dogs 4.5-5.9 kg), and 16 mg (for dogs 12-17.9 kg). Tablets should not be broken or split. Your veterinarian will prescribe the appropriate size based on your dog's weight.
Can I give Apoquel to puppies?
Apoquel is FDA-approved for dogs 12 months of age and older. It should not be used in puppies under 12 months. If your puppy has allergies or itching, consult your veterinarian for age-appropriate treatment options.
How long does it take for Apoquel to work?
Apoquel starts working within 4 hours to control itching and inflammation associated with allergic dermatitis in dogs. Maximum effect is typically seen within 24 hours. Initial therapy (twice daily dosing) continues for up to 14 days before transitioning to once-daily maintenance.
Can I give Apoquel with food?
Yes, Apoquel can be given with or without food. Giving it with food may help dogs who experience mild stomach upset. The medication is absorbed effectively regardless of whether it's given with a meal.
What is the difference between initial and maintenance Apoquel dosing?
Initial therapy uses the same dose (0.4-0.6 mg/kg) but is given twice daily for up to 14 days to quickly control severe itching. Maintenance therapy reduces to once daily at the same dose per administration for long-term allergy management. Never exceed 14 days of twice-daily dosing.
What conditions does Apoquel treat?
Apoquel (oclacitinib) is FDA-approved to control itching associated with allergic dermatitis and to control atopic dermatitis in dogs. It works by blocking Janus kinase enzymes that trigger itching and inflammation. It's not a steroid and doesn't treat infections.
Are there side effects of Apoquel in dogs?
Common side effects may include vomiting, diarrhea, decreased appetite, and lethargy. Apoquel suppresses part of the immune system, so dogs may be more susceptible to infections. Regular veterinary monitoring is recommended, especially for long-term use. Report any unusual symptoms to your vet.
Can I split or crush Apoquel tablets?
No, Apoquel tablets should not be split, broken, or crushed. The tablets are film-coated and designed to be given whole. If the available tablet sizes don't match your dog's required dose, consult your veterinarian for alternative solutions.
Sources & References
The dosing figures, tablet sizes, and safety information on this page are compiled from the manufacturer's FDA-approved product label and recognized veterinary references, not from this site's own judgment. This tool is informational only — always confirm dosing and suitability with your veterinarian.
- U.S. Food & Drug Administration / DailyMed — APOQUEL (oclacitinib maleate) FDA-approved prescribing label — indications, dosage and administration, contraindications, and warnings.
- U.S. FDA Center for Veterinary Medicine — Freedom of Information Summary, NADA 141-345 (approved June 9, 2023) — FDA review supporting the Apoquel approval.
- Merck Veterinary Manual — Atopic Dermatitis in Dogs · Immunomodulators for Integumentary Disease in Animals — independent veterinary reference on JAK inhibitor use, dosing, and adverse effects.
- Zoetis — manufacturer product page for Apoquel.
This page is compiled and reviewed against the sources above; it is not written or reviewed by a veterinarian. See our About page for details on how this site is run.
Medical Disclaimer
This calculator is for informational purposes only and is not a substitute for professional veterinary advice. Apoquel (oclacitinib) is a prescription medication that should only be used under the guidance of a licensed veterinarian. Do not administer Apoquel without a valid prescription. Always consult with your veterinarian before starting, changing, or stopping any medication for your pet. The creators of this calculator assume no responsibility for decisions made based on this information.
Never start, stop, or change your dog's medication based solely on this calculator. If your dog shows signs of an adverse reaction (vomiting, diarrhea, lethargy, signs of infection, or unusual lumps), contact your veterinarian promptly.