Apoquel
Oclacitinib maleate
- Class: Janus Kinase (JAK) Inhibitor
- Manufacturer: Zoetis
- Onset: Within 4 hours
- Duration: 12-24 hours per dose
- Cost: $2-4 per tablet ($60-120/month)
Cytopoint
Lokivetmab
- Class: Monoclonal Antibody
- Manufacturer: Zoetis
- Onset: Within 1 day
- Duration: 4-8 weeks per injection
- Cost: $50-150 per injection (every 4-8 weeks)
Side-by-Side Comparison
| Category | Apoquel | Cytopoint |
|---|---|---|
| Administration | Daily oral tablet | Injection every 4-8 weeks |
| Speed of Relief | Within 4 hours✓ | Within 1 day |
| Duration | 12-24 hours per dose | 4-8 weeks per injection✓ |
| Side Effects | More common (GI, infections) | Rare (injection site only)✓ |
| Cost | $60-120/month | $50-150 every 4-8 weeks |
| Mechanism | JAK inhibitor (blocks itch signals) | Antibody (neutralizes IL-31) |
How They Work
Apoquel
Blocks JAK1 and JAK3 enzymes that trigger itch signals
Cytopoint
Neutralizes canine interleukin-31 (IL-31), a key itch cytokine
Side Effects Comparison
Apoquel Side Effects
- •Vomiting
- •Diarrhea
- •Decreased appetite
- •Lethargy
- •Increased susceptibility to infections
Cytopoint Side Effects
- •Injection site reactions (rare)
- •Lethargy
- •Vomiting (rare)
When to Choose Each Medication
Choose Apoquel if:
- ✓You need immediate itch relief (works within 4 hours)
- ✓Your dog has seasonal allergies and needs flexible dosing
- ✓You prefer giving pills at home
- ✓Your dog tolerates oral medications well
- ✓You want the ability to stop medication quickly if needed
Choose Cytopoint if:
- ✓Your dog is difficult to pill
- ✓You prefer monthly vet visits over daily medication
- ✓Your dog has had side effects with Apoquel
- ✓Long-term continuous therapy is needed
- ✓Your dog has a sensitive stomach
Our Recommendation
Both medications are excellent choices for managing allergic itch in dogs. Choose based on your dog's needs, your lifestyle, and your veterinarian's recommendation.
Always consult with your veterinarian before starting, changing, or stopping any medication for your pet.
Frequently Asked Questions
Is Apoquel or Cytopoint better for my dog?
Both are highly effective for allergic itch. Apoquel works faster (4 hours) and can be stopped immediately, making it ideal for seasonal allergies. Cytopoint has fewer side effects and lasts 4-8 weeks, making it better for dogs who are difficult to pill or need long-term therapy. Your vet can help determine which is best for your dog's specific situation.
Can Apoquel and Cytopoint be used together?
Yes, Apoquel and Cytopoint can be safely used together under veterinary supervision. This combination is sometimes used for dogs with severe allergies that don't respond adequately to either medication alone. However, this should only be done under your veterinarian's guidance.
Which is safer: Apoquel or Cytopoint?
Cytopoint is generally considered safer with fewer side effects. Since it's a monoclonal antibody targeting only IL-31, it doesn't affect the immune system as broadly as Apoquel. Apoquel can increase susceptibility to infections and may not be suitable for dogs with certain conditions. Both are FDA-approved and safe when used as directed.
Which is cheaper: Apoquel or Cytopoint?
The cost is similar over time. Apoquel costs about $60-120/month for daily tablets. Cytopoint costs $50-150 per injection given every 4-8 weeks. For small dogs, Cytopoint may be cheaper; for large dogs, Apoquel is often more economical. Factor in vet visit costs for Cytopoint injections.
Other Drug Comparisons
Need to Calculate Apoquel Dosage?
Use our free calculator to determine the correct Apoquel dose for your dog.
Apoquel Dosage Calculator →Medical Disclaimer
This calculator is for informational purposes only and is not a substitute for professional veterinary advice. Apoquel (oclacitinib) is a prescription medication that should only be used under the guidance of a licensed veterinarian. Do not administer Apoquel without a valid prescription. Always consult with your veterinarian before starting, changing, or stopping any medication for your pet. The creators of this calculator assume no responsibility for decisions made based on this information.